Little Italy, sometimes referred to as College Street West or Latintown, is a district in Toronto. It is well known for its numerous Italian restaurants and businesses. There is also a significant Latin American and Portuguese community in the general area.

Little Italy is centred around a restaurant/bar/shopping strip along College Street, the heart of which is the intersection of College and Grace Streets and the adjacent residential area, but spreading out between Bathurst Street and Dufferin Street. The area south of College to Dundas Street is almost always considered part of Little Italy. The area north of Harbord Avenue is also known as Palmerston or Bickford Park and features some excellent real estate offerings.

College Street was fully laid out in the area by 1900 and the area was filled with commercial buildings from the early 1900s. College Street is fronted by two- and three-storey buildings, with commercial uses on the ground floor and condos or apartments on the upper floors.

From Manning Avenue to the east to Shaw Street to the west, there are numerous sidewalk cafes, including Cafe Diplomatico, Bitondos Pizza, Bar Italia, Riviera Bakery, and Sicilian Ice Cream. The curved street between Grace and Crawford was laid out with larger sidewalks. This section was laid out later to cross Garrison Creek, which was buried under Crawford. The wider sidewalks have allowed more extensive cafe patios in this area.

At Clinton, on the north side, is the Royal repertory cinema, which was recently renovated and has an upgraded projection system as it is used for movie editing purposes during the day and repertory cinema in the evenings. While the commercial units are dominated by cafes and restaurants, there are numerous other small businesses serving the neighbourhood.

The side streets in Little Italy are mostly detached or semi-detached single family homes dating to the early-1900s Edwardian period, with front porches and on smaller lots, as was the custom at the time.

Italians arrived in Toronto in large numbers during the early 20th century. Italians first settled in an area then known as The Ward, centered around University Avenue and College Street. By the 1920s, most Italians had moved west of Bathurst Street and the College-Clinton area had emerged as the city's major Little Italy. The affordable Edwardian homes that line the side streets of this neighbourhood were bought by Italian immigrants, many of whom found work on the railways and in road construction. Italians started businesses on and around College Street.

Little Italy is much more ethnically diverse today. Italian-Canadians born during the Post-World War II baby boom and Italian immigrants from the 1960s onwards have tended to settle in the Corso Italia neighbourhood around St. Clair Avenue and Dufferin Street and in Toronto's suburbs.

Little Italy has also become popular with young people and young professionals because of its vibrant nightlife and its proximity to the downtown core. Since the 1980s, many young professionals have bought homes or condominiums in the neighbourhood.